Product Availability Update

Promega Manufacturing and Delivery Systems continue to be fully operational during the COVID-19 outbreak. Our teams are in regular contact with suppliers and distributors worldwide and are taking all steps necessary to address both demands for diagnostic tools and reliable delivery of all products as quickly as possible. Learn more

Our website does not fully support your browser.

We've detected that you are using an older version of Internet Explorer. Your commerce experience may be limited. Please update your browser to Internet Explorer 11 or above.

We believe this site might serve you best:

United States

United States

Language: English

Promega's Cookie Policy

Our website uses functional cookies that do not collect any personal information or track your browsing activity. When you select your country, you agree that we can place these functional cookies on your device.

Biologics Drug Discovery


In contrast to small molecule drugs that are chemically synthesized and have a known structure, biologics are large molecules with complex, heterogeneous structures that are often unstable and sensitive to external conditions. Due to their high degree of complexity, the development of biologics drugs requires a comprehensive set of quantitative, accurate and precise bioanalytical tools.

We provide a broad portfolio of functional bioassays and protein characterization tools to accelerate your biologics drug discovery and development. Explore these pages to learn about Promega products, quality standards, scientific and manufacturing support available for biologics drug discovery. We are here to help you in your drug discovery pursuits.

word-cloud-v4

Introduction to Biologics Drug Discovery

Biological therapeutics (biologics) are revolutionizing the treatment of cancer and immune inflammatory disease states. Initially, biologic drugs were limited to simple peptide molecules (e.g., insulin). However, in recent years, with the progression of innovative technological approaches, biologics comprised of monoclonal antibodies, fusion proteins, vaccines, cell and gene therapies have been created and deployed in the treatment of disease. To standardize practices in the development of these therapies, authorities from regulatory agencies and the pharmaceutical industry have established organizations, such as the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) and the U.S. Pharmacopeia (USP), that issue guidelines to help ensure the production of safe, effective and high-quality medicines. These policies are not only important for novel innovator biologics, but also for the generation of biosimilar molecules. Biosimilars are biologics that are highly similar to and possess no clinically meaningful difference from a previously approved reference product. 

Because of the inherent complexity and variability of these therapeutics, robust characterization tools are essential throughout the drug discovery and development process to ensure on target mechanism of action, drug potency and biomanufacturing process consistency. As an example, cell based functional bioassays enable quantitative interrogation and validation of a biologic molecule’s target specificity (e.g., immune checkpoint receptor) or mechanistic endpoint (e.g. ADCC). In addition, reagents that facilitate streamlined antibody purification and site-specific enzymes for mass spectroscopy-based analysis are crucial tools in biologics development workflows.

Support for Contract Research Organizations (CROs)

Improve your clients’ biologics development with the industry-leading technology of Promega bioassays.

Learn More

大香伊在人线国产观看?大香伊在人线综合 大萫焦视频